Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional Regulation of APOBEC3G, a Cytidine Deaminase That Hypermutates Human Immunodeficiency Virus

6 Aug 2004

Abstract excerpt

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G (APOBEC3G) is an antiretroviral deoxycytidine deaminase that lethally hypermutates human immunodeficiency virus type 1 (HIV-1) but is itself neutralized by the HIV-1-encoded viral infectivity factor. Accordingly, APOBEC3G occurs specifically in human T lymphocytic cell lines that contain this antiviral defense, including H9. Since the substrate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical and Molecular Research
Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15297452
DOI: 10.1074/jbc.m406760200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional Regulation of APOBEC3G, a Cytidine Deaminase That Hypermutates Human Immunodeficiency VirusPMID 15297452Read ↗

Regulated Production and Anti-HIV Type 1 Activities of Cytidine Deaminases APOBEC3B, 3F, and 3GSemantic proximity Read ↗

Enzymatically active APOBEC3G is required for efficient inhibition of human immunodeficiency virus type 1.Semantic proximity Read ↗

APOBEC3G targets human T-cell leukemia virus type 1.Semantic proximity Read ↗

T Cells Contain an RNase-Insensitive Inhibitor of APOBEC3G Deaminase ActivitySemantic proximity Read ↗

APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G.Semantic proximity Read ↗

Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment.Semantic proximity Read ↗

The Cytidine Deaminase APOBEC3 Family Is Subject to Transcriptional Regulation by p53.Semantic proximity Read ↗

Inhibition of \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{amssymb} \usepackage{amsfonts} \usepackage{amsmath} \pagestyle{empty} \begin{document} \(\mathrm{tRNA}_{3}^{\mathrm{Lys}}\) \end{document}-Primed Reverse Transcription by Human APOBEC3G during Human Immunodeficiency Virus Type 1 ReplicationSemantic proximity Read ↗

Suppression of HIV-1 Infection by APOBEC3 Proteins in Primary Human CD4 <sup>+</sup> T Cells Is Associated with Inhibition of Processive Reverse Transcription as Well as Excessive Cytidine DeaminationSemantic proximity Read ↗

Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanismSemantic proximity Read ↗

Apolipoprotein B mRNA–Editing Enzyme, Catalytic Polypeptide–Like 3G: A Possible Role in the Resistance to HIV of HIV‐Exposed Seronegative IndividualsSemantic proximity Read ↗

APOBEC3G rescues cells from the deleterious effects of DNA damageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.