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Article

Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment.

Retrovirology - 30 Apr 2012

Monajemi Mahdis, Woodworth Claire F, Benkaroun Jessica, Grant Michael, Larijani Mani

Abstract excerpt

The enzyme APOBEC3G (A3G) mutates the human immunodeficiency virus (HIV) genome by converting deoxycytidine (dC) to deoxyuridine (dU) on minus strand viral DNA during reverse transcription. A3G restricts viral propagation by degrading or incapacitating the coding ability of the HIV genome. Thus, this enzyme has been perceived as an innate immune barrier to viral replication whilst adaptive immunity responses...

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Topics

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Share to Adaptation, Biological
Share to Adaptive Immunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to APOBEC Deaminases

Share to Cytidine Deaminase

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Share to Gene Expression Regulation, Viral

Share to Immune Evasion

Source

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Identifiers

PMID: 22546055
DOI: 10.1186/1742-4690-9-35
PMCID: PMC3416701

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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