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Article

Maturation of influenza A virus hemagglutinin--estimates of the pH encountered during transport and its regulation by the M2 protein.

Virology - 1 Sept 1992

Grambas S, Hay A J

Abstract excerpt

The susceptibility of H7 influenza A viruses to the M2-mediated alteration in HA resulting from treatment with amantadine or rimantadine depends both on the pH stability of HA and the pH encountered during transport to the plasma membrane of the particular virus-infected cell. pH stabilities of a range of virus mutant HAs exhibited an inverse correlation with drug sensitivity and the proportion of low-pH HA...

Topics

Amantadine
Animals
Biological Transport
Cell Line
Genes, Viral
Genetic Complementation Test
Hemagglutinin Glycoproteins, Influenza Virus
Hemagglutinins, Viral
Hydrogen-Ion Concentration
Influenza A virus
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rimantadine

Viral Matrix Proteins

Source

Identifiers

PMID: 1529523
DOI: 10.1016/0042-6822(92)91187-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1529523-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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