Article
Influence of amantadine resistance mutations on the pH regulatory function of the M2 protein of influenza A viruses.
Virology - 1 Dec 1992
Grambas S, Bennett M S, Hay A J
Abstract excerpt
Mutations in the influenza M2 membrane protein which confer resistance to the antiviral drug amantadine are exclusively located within the transmembrane region of the molecule. The influence of specific amino acid substitutions on the activity of the M2 protein in influenza A virus-infected cells is assessed in this report by their effects upon haemagglutinin (HA) stability and virus growth. A number of amino...
Topics
- Amantadine
- Amino Acid Sequence
- Drug Resistance, Microbial
- Genetic Complementation Test
- Genetic Variation
- Hemagglutinins, Viral
- Hydrogen-Ion Concentration
- Influenza A virus
- Molecular Sequence Data
- Mutagenesis
- Mutation