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Article

Influenza B virus BM2 protein has ion channel activity that conducts protons across membranes.

Developmental cell - 1 Jul 2003

Mould Jorgen A, Paterson Reay G, Takeda Makoto, Ohigashi Yuki, Venkataraman Padma, Lamb Robert A, Pinto Lawrence H

Abstract excerpt

Successful uncoating of the influenza B virus in endosomes is predicted to require acidification of the interior of the virus particle. We report that a virion component, the BM2 integral membrane protein, when expressed in Xenopus oocytes or in mammalian cells, causes acidification of the cells and possesses ion channel activity consistent with proton conduction. Furthermore, coexpression of BM2 with...

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PMID: 12852861
DOI: 10.1016/s1534-5807(03)00190-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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