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Article

Mechanistic insights from functional characterization of an unnatural His37 mutant of the influenza A/M2 protein.

Biochimica et biophysica acta - 1 Apr 2014

Polishchuk Alexei L, Cristian Lidia, Pinto Lawrence H, Lear James D, DeGrado William F

Abstract excerpt

The influenza A/M2 protein is a homotetrameric single-pass integral membrane protein encoded by the influenza A viral genome. Its transmembrane domain represents both a crucial drug target and a minimalistic model system for transmembrane proton transport and charge stabilization. Recent structural and functional studies of M2 have suggested that the proton transport mechanism involves sequential extraviral...

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Identifiers

PMID: 24269540
DOI: 10.1016/j.bbamem.2013.11.011
PMCID: PMC3943701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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