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Article

Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 2005

Rashidian Juliet, Iyirhiaro Grace, Aleyasin Hossein, Rios Mario, Vincent Inez, Callaghan Steven, Bland Ross J, Slack Ruth S, During Matthew J, Park David S

Abstract excerpt

The mechanisms involving neuronal death after ischemic/hypoxic insult are complex, involving both rapid (excitotoxic) and delayed (apoptotic-like) processes. Recent evidence suggests that cell cycle regulators such as cyclin-dependent kinases are abnormally activated in neuropathological conditions, including stroke. However, the function of this activation is unclear. Here, we provide evidence that inhibition of...

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Source

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Identifiers

PMID: 16166266
DOI: 10.1073/pnas.0500099102
PMCID: PMC1236525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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