Article

Type 1-polarized DC immunotherapeutic contains heterogeneous populations with IL-12p70 production restricted to a rare subset

2026-05-02

Abstract excerpt

<h4>ABSTRACT</h4> Monocyte-derived DC therapies programmed for robust IL-12p70 production have been associated with favorable outcomes in cancer clinical trials. However, clinical responses remain inconsistent even under standardized protocols, and the cellular basis for this variability is unknown. We leveraged single-cell multiomics to characterize two widely used DC platforms, the high-IL-12p70-producing alpha...

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Literature Corpus work: aa379bcf-aee3-5b28-b43e-d5a80de3761b
DOI: 10.64898/2026.04.29.721620

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Type 1-polarized DC immunotherapeutic contains heterogeneous populations with IL-12p70 production restricted to a rare subsetDOI 10.64898/2026.04.29.721620Read

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