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Article

Unc-45 mutations in Caenorhabditis elegans implicate a CRO1/She4p-like domain in myosin assembly.

The Journal of cell biology - 30 Nov 1998

Barral J M, Bauer C C, Ortiz I, Epstein H F

Abstract excerpt

The Caenorhabditis elegans unc-45 locus has been proposed to encode a protein machine for myosin assembly. The UNC-45 protein is predicted to contain an NH2-terminal domain with three tetratricopeptide repeat motifs, a unique central region, and a COOH-terminal domain homologous to CRO1 and She4p. CRO1 and She4p are fungal proteins required for the segregation of other molecules in budding, endocytosis, and...

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Identifiers

PMID: 9832550
DOI: 10.1083/jcb.143.5.1215
PMCID: PMC2133068

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Related research

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Research trail→

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Unc-45 mutations in Caenorhabditis elegans implicate a CRO1/She4p-like domain in myosin assembly.PMID 9832550Read ↗

The UCS family of myosin chaperonesSemantic proximity Read ↗

The UNC-45 myosin chaperone: from worms to flies to vertebrates.Semantic proximity Read ↗

Challenging muscle homeostasis uncovers novel chaperone interactions in Caenorhabditis elegansSemantic proximity Read ↗

Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin.Semantic proximity Read ↗

Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans.Semantic proximity Read ↗

The myosin-binding UCS domain but not the Hsp90-binding TPR domain of the UNC-45 chaperone is essential for function in Caenorhabditis elegans.Semantic proximity Read ↗

Hsp90 protein in fission yeast Swo1p and UCS protein Rng3p facilitate myosin II assembly and function.Semantic proximity Read ↗

Mutation of the Ser18 phosphorylation site on the sole Saccharomyces cerevisiae UCS protein, She4, can compromise high-temperature survival.Semantic proximity Read ↗

Pathogenic Variants in the Myosin Chaperone UNC-45B Cause Progressive Myopathy with Eccentric Cores.Semantic proximity Read ↗

Mutations in conserved residues of the myosin chaperone UNC-45 result in both reduced stability and chaperoning activity.Semantic proximity Read ↗

The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafish.Semantic proximity Read ↗

The unc-45 gene of Caenorhabditis elegans is an essential muscle-affecting gene with maternal expression.Semantic proximity Read ↗

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