Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

X-linked sex-determining region Y box 3 (SOX3) gene mutations are uncommon in men with idiopathic oligoazoospermic infertility.

The Journal of clinical endocrinology and metabolism - 1 Aug 2004

Raverot Gerald, Lejeune Herve, Kotlar Tom, Pugeat Michel, Jameson J Larry

Abstract excerpt

The X-linked sex-determining region Y box 3 (SOX3) gene is expressed in the developing gonads and brain. Sox3-null mice developed according to genetic sex, but the hemizygous null males were hypogonadal, with extensive Sertoli cell vacuo-lization, loss of germ cells, and reduced sperm count. We hypothesized that SOX3 mutations might occur in a subset of infertility patients. Genomic DNA samples from 56 infertile...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenine
Share to Cytosine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine

Share to High Mobility Group Proteins

Share to Infertility, Male

Share to Oligospermia

Share to SOXB1 Transcription Factors

Share to Thymine

Source

Identifiers

PMID: 15292361
DOI: 10.1210/jc.2004-0191

Genes

SOX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

X-linked sex-determining region Y box 3 (SOX3) gene mutations are uncommon in men with idiopathic oligoazoospermic infertility.PMID 15292361Read ↗

Mutations of SOX30 are identified in azoospermic human patients and reduce sperm in mice†.Semantic proximity Read ↗

Mutation analysis of subjects with 46, XX sex reversal and 46, XY gonadal dysgenesis does not support the involvement of SOX3 in testis determination.Semantic proximity Read ↗

SIN3A mutations are rare in men with azoospermia.Semantic proximity Read ↗

Mutations involving the SRY-related gene SOX8 are associated with a spectrum of human reproductive anomaliesSemantic proximity Read ↗

A rare synaptonemal complex protein 3 gene variant in unexplained female infertility.Semantic proximity Read ↗

Sox3 Functions in a Cell-Autonomous Manner to Regulate Spermatogonial Differentiation in MiceSemantic proximity Read ↗

SOX3 Overdosage Permits Normal Sex Development in Females with Random X Inactivation.Semantic proximity Read ↗

XX male sex reversal with genital abnormalities associated with a de novo SOX3 gene duplication.Semantic proximity Read ↗

Null mutation of the transcription factor inhibitor of DNA binding 3 (ID3) in male mice adversely impacts on fertility and reproductive outcome.Semantic proximity Read ↗

Investigation of mutations in the synaptonemal complex protein 3 (SYCP3) gene among azoospermic infertile male patients in the Turkish population.Semantic proximity Read ↗

SOX3 promotes generation of committed spermatogonia in postnatal mouse testesSemantic proximity Read ↗

Azoospermia in patients heterozygous for a mutation in SYCP3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.