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Article

Azoospermia in patients heterozygous for a mutation in SYCP3.

Lancet (London, England) - 22 Nov 2003

Miyamoto Toshinobu, Hasuike Shiga, Yogev Leah, Maduro Maria R, Ishikawa Mutsuo, Westphal Heiner, Lamb Dolores J

Abstract excerpt

BACKGROUND: Many cases of male infertility are diagnosed as idiopathic, reflecting poor understanding of the molecular defects underlying the abnormality. As more gene mutations causing male infertility in mice become known, there are improving prospects that knowledge about the genetic aetiology...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14643120
DOI: 10.1016/S0140-6736(03)14845-3

Genes

SYCP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-14643120-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Azoospermia in patients heterozygous for a mutation in SYCP3.PMID 14643120Read ↗

Mutations in Genes Coding for Synaptonemal Complex Proteins and Their Impact on Human Fertility.Semantic proximity Read ↗

Investigation of mutations in the synaptonemal complex protein 3 (SYCP3) gene among azoospermic infertile male patients in the Turkish population.Semantic proximity Read ↗

A rare synaptonemal complex protein 3 gene variant in unexplained female infertility.Semantic proximity Read ↗

A rare frameshift mutation inSYCP1is associated with human male infertilitySemantic proximity Read ↗

A homozygous frameshift variant in SYCP2 caused meiotic arrest and non-obstructive azoospermia.Semantic proximity Read ↗

<i>SYCP2</i> translocation-mediated dysregulation and frameshift variants cause human male infertilitySemantic proximity Read ↗

Mouse modeling of familial human SYCE1 c.197-2A>G splice site mutation leads to meiotic recombination failure and non-obstructive azoospermia.Semantic proximity Read ↗

Translation of the synaptonemal complex component Sycp3 is enhanced in vivo by the germ cell specific regulator DazlSemantic proximity Read ↗

Familial primary ovarian insufficiency associated with an SYCE1 point mutation: defective meiosis elucidated in humanized mice.Semantic proximity Read ↗

Novel exon mutation in SYCE1 gene is associated with non-obstructive azoospermia.Semantic proximity Read ↗

Mutations of the SYCP3 gene in women with recurrent pregnancy loss.Semantic proximity Read ↗

SYCP2 Translocation-Mediated Dysregulation and Frameshift Variants Cause Human Male Infertility.Semantic proximity Read ↗

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