Article
Mutations of SOX30 are identified in azoospermic human patients and reduce sperm in mice†.
Biology of reproduction - 16 Mar 2026
Ren Sen, Chen Niuniu, Lu Shuai, Leng Tian, Kang Zhenlong, Xu Chen, Xie Zhiming, Han Shenglin, Lu Chenyu, Wang Cheng, Hu Zhibin, Lin Changsong, Guan Yichun, Gu Yayun, Ye Lan
Abstract excerpt
Sox proteins constitute a family of transcription factors now thought to play essential roles in cell fate decisions and tissue regeneration. SOX30 is a testis-specific transcription regulator for activating the postmeiotic haploid gene program, and knockout of Sox30 results in defects in meiotic exit with an arrest at the early stage of round spermatids. Here, we aim to investigate the impact of human SOX30...
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