Article
SIN3A mutations are rare in men with azoospermia.
Andrologia - 1 Nov 2015
Miyamoto T, Koh E, Tsujimura A, Miyagawa Y, Minase G, Ueda Y, Namiki M, Sengoku K
Abstract excerpt
A loss of function of the murine Sin3A gene resulted in male infertility with Sertoli cell-only syndrome (SCOS) phenotype in mice. Here, we investigated the relevance of this gene to human male infertility with azoospermia caused by SCOS. Mutation analysis of SIN3A in the coding region was performed on 80 Japanese patients. However, no variants could be detected. This study suggests a lack of association of SIN3A...
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