Article
A rare synaptonemal complex protein 3 gene variant in unexplained female infertility.
Molecular human reproduction - 1 Apr 2011
Nishiyama S, Kishi T, Kato T, Suzuki M, Bolor H, Nishizawa H, Iwata N, Udagawa Y, Kurahashi H
Abstract excerpt
Synaptonemal complex protein 3 (SYCP3) plays a critical role in homologous chromosome pairing and recombination in meiosis, and mice deficient in this gene show infertility in males and subfertility in females. The aim of our current study was to determine whether genetic alterations in the SYCP3 gene are associated with female infertility in humans. We examined sequence variations of the SYCP3 gene in genomic...
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