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Article

SOX3 promotes generation of committed spermatogonia in postnatal mouse testes

21 Apr 2020

Abstract excerpt

SOX3 is a transcription factor expressed within the developing and adult nervous system where it mostly functions to help maintain neural precursors. Sox3 is also expressed in other locations, notably within the spermatogonial stem/progenitor cell population in postnatal testis. Independent studies have shown that Sox3 null mice exhibit a spermatogenic block as young adults, the mechanism of which remains poorly...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 32317665
DOI: 10.1038/s41598-020-63290-3

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