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Article

Genome-wide linkage analysis reveals evidence for four new susceptibility loci for familial euthyroid goiter.

The Journal of clinical endocrinology and metabolism - 1 Aug 2004

Bayer Yvonne, Neumann Susanne, Meyer Birgit, Rüschendorf Franz, Reske Andreas, Brix Thomas, Hegedüs Laszlo, Langer Pavel, Nürnberg Peter, Paschke Ralf

Abstract excerpt

Euthyroid goiter is characterized by diffuse or nodular enlargement of the thyroid gland. Iodine deficiency and cigarette smoking have been identified as important environmental factors. However, family and twin pair studies suggest a strong genetic predisposition. Therefore, we performed the first extended genome-wide scan to identify susceptibility loci that predispose for euthyroid goiter using 450...

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PMID: 15292347
DOI: 10.1210/jc.2003-032096

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