Article
Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.
Nature genetics - 1 Feb 2026
White Samantha L, Brasher Maizy S, Pattee Jack, Zhou Wei, Chapman Sinéad, Jee Yon Ho, Bell Caitlin C, Jamil Taylor L, Barrio Martin, Arehart Christopher H, Evans Luke M, Hirbo Jibril, Cox Nancy J, Straub Peter, Namba Shinichi, Bertucci-Richter Emily, Guare Lindsay, Edris Ahmed, Morris Sam, Mulford Ashley J, Zhang Haoyu, Fennessy Brian, Tobin Martin D, Chen Jing, Williams Alexander T, John Catherine, van Heel David A, Mathur Rohini, Finer Sarah, Moksnes Marta R, Brumpton Ben M, Åsvold Bjørn Olav, Peculis Raitis, Rovite Vita, Konrade Ilze, Wang Ying, Crooks Kristy, Chavan Sameer, Fisher Matthew J, Rafaels Nicholas, Lin Meng, Shortt Jonathan A, Sanders Alan R, Whiteman David C, MacGregor Stuart, Medland Sarah E, Thorsteinsdóttir Unnur, Stefánsson Kári, Karaderi Tugce, Egan Kathleen M, Bocklage Therese, McCrary Hilary C, Riedlinger Gregory, Salhia Bodour, Shriver Craig, Phan Minh D, Farlow Janice L, Edge Stephen, Kaur Varinder, Churchman Michelle L, Rounbehler Robert J, Brock Pamela L, Ringel Matthew D, Pividori Milton, Schweppe Rebecca, Raeburn Christopher D, Walters Robin G, Chen Zhengming, Li Liming, Matsuda Koichi, Okada Yukinori, Zöllner Sebastian, Verma Anurag, Preuss Michael H, Kenny Eimear, Hendricks Audrey E, Fishbein Lauren, Kraft Peter, Daly Mark J, Neale Benjamin M, Martin Alicia R, Cole Joanne B, Haugen Bryan R, Gignoux Christopher R, Pozdeyev Nikita
Abstract excerpt
Thyroid diseases are common and highly heritable. We performed a meta-analysis of genome-wide association studies from 19 biobanks for five thyroid diseases: thyroid cancer (ThC), benign nodular goiter, Graves' disease, lymphocytic thyroiditis and primary hypothyroidism. We analyzed genetic association data from ~2.9 million genomes and identified 313 known and 570 new independent loci linked to thyroid diseases....
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