Article
The genetics of euthyroid familial goiter.
Trends in endocrinology and metabolism: TEM - 1 Sept 2005
Böttcher Yvonne, Eszlinger Markus, Tönjes Anke, Paschke Ralf
Abstract excerpt
In endemic goiters, thyroidal enlargement reflects an increase in cell proliferation triggered by low dietary iodine. However, not all individuals in the same iodine-deficient regions develop a goiter, and iodine supplementation does not prevent goiter development in all treated subjects. Familial clustering of goiters, usually with an autosomal-dominant pattern of inheritance, has repeatedly been reported....
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