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Article

A cluster of constitutive mutations affecting the C-terminus of the redox-sensitive SoxR transcriptional activator.

Nucleic acids research - 11 Aug 1994

Nunoshiba T, Demple B

Abstract excerpt

Activation of Escherichia coli oxidative stress regulon genes (sodA, zwf, fumC, nfo, etc.) is mediated by a two-stage regulatory system: the redox-sensitive SoxR protein transcriptionally activates the soxS gene, whose product then stimulates transcription of the regulon genes. Previous experiments showed that limited 3' truncation of soxR gene causes constitutive soxRS expression. DNA sequence analysis of the...

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Identifiers

PMID: 8065907
DOI: 10.1093/nar/22.15.2958
PMCID: PMC310261

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A cluster of constitutive mutations affecting the C-terminus of the redox-sensitive SoxR transcriptional activator.PMID 8065907Read ↗

Transcription-defective soxR mutants of Escherichia coli: isolation and in vivo characterization.Semantic proximity Read ↗

Functional analysis of SoxR residues affecting transduction of oxidative stress signals into gene expression.Semantic proximity Read ↗

The redox-regulated SoxR protein acts from a single DNA site as a repressor and an allosteric activator.Semantic proximity Read ↗

A reducing system of the superoxide sensor SoxR in Escherichia coli.Semantic proximity Read ↗

Two-stage induction of the soxRS (superoxide response) regulon of Escherichia coli.Semantic proximity Read ↗

Functional Characterization of RseC in the SoxR Reducing System and Its Role in Oxidative Stress Response in Escherichia coli.Semantic proximity Read ↗

Redox signal transduction: mutations shifting [2Fe-2S] centers of the SoxR sensor-regulator to the oxidized form.Semantic proximity Read ↗

A soxRS-constitutive mutation contributing to antibiotic resistance in a clinical isolate of Salmonella enterica (Serovar typhimurium).Semantic proximity Read ↗

Constitutive soxR mutations contribute to multiple-antibiotic resistance in clinical Escherichia coli isolates.Semantic proximity Read ↗

A comprehensive alanine scanning mutagenesis of the Escherichia coli transcriptional activator SoxS: identifying amino acids important for DNA binding and transcription activation.Semantic proximity Read ↗

soxR, a locus governing a superoxide response regulon in Escherichia coli K-12.Semantic proximity Read ↗

Differential activities of the SoxR protein of Escherichia coli: SoxS is not required for gene activation under iron deprivation.Semantic proximity Read ↗

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