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Article

A reducing system of the superoxide sensor SoxR in Escherichia coli.

The EMBO journal - 2 Jun 2003

Koo Mi-Sun, Lee Joon-Hee, Rah So-Yeon, Yeo Won-Sik, Lee Jin-Won, Lee Kang-Lok, Koh Young-Sang, Kang Sa-Ouk, Roe Jung-Hye

Abstract excerpt

The soxRS regulon functions in protecting Escherichia coli cells against superoxide and nitric oxide. When SoxR is activated by oxidation of its [2Fe-2S] cluster, it increases the synthesis of SoxS, which then activates its target gene expression. How the oxidized SoxR returns to and is maintained in its reduced state has been under question. To identity genes that constitute the SoxR-reducing system, we screened...

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Identifiers

PMID: 12773378
DOI: 10.1093/emboj/cdg252
PMCID: PMC156749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A reducing system of the superoxide sensor SoxR in Escherichia coli.PMID 12773378Read ↗

Functional Characterization of RseC in the SoxR Reducing System and Its Role in Oxidative Stress Response in Escherichia coli.Semantic proximity Read ↗

Transcription-defective soxR mutants of Escherichia coli: isolation and in vivo characterization.Semantic proximity Read ↗

Two-stage induction of the soxRS (superoxide response) regulon of Escherichia coli.Semantic proximity Read ↗

Regulation of the soxRS oxidative stress regulon. Reversible oxidation of the Fe-S centers of SoxR in vivo.Semantic proximity Read ↗

Rational Tuning of Superoxide Sensitivity in SoxR, the [2Fe-2S] Transcription Factor: Implications of Species-Specific Lysine Residues.Semantic proximity Read ↗

Redox signal transduction: mutations shifting [2Fe-2S] centers of the SoxR sensor-regulator to the oxidized form.Semantic proximity Read ↗

Functional analysis of SoxR residues affecting transduction of oxidative stress signals into gene expression.Semantic proximity Read ↗

The redox-regulated SoxR protein acts from a single DNA site as a repressor and an allosteric activator.Semantic proximity Read ↗

A cluster of constitutive mutations affecting the C-terminus of the redox-sensitive SoxR transcriptional activator.Semantic proximity Read ↗

Constitutive soxR mutations contribute to multiple-antibiotic resistance in clinical Escherichia coli isolates.Semantic proximity Read ↗

soxR, a locus governing a superoxide response regulon in Escherichia coli K-12.Semantic proximity Read ↗

A soxRS-constitutive mutation contributing to antibiotic resistance in a clinical isolate of Salmonella enterica (Serovar typhimurium).Semantic proximity Read ↗

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