Article
Rational Tuning of Superoxide Sensitivity in SoxR, the [2Fe-2S] Transcription Factor: Implications of Species-Specific Lysine Residues.
Biochemistry - 17 Jan 2017
Fujikawa Mayu, Kobayashi Kazuo, Tsutsui Yuko, Tanaka Takahiro, Kozawa Takahiro
Abstract excerpt
In Escherichia coli, the [2Fe-2S] transcriptional factor, SoxR, functions as a sensor of oxidative stress. The transcriptional activity in SoxR is regulated by the reversible oxidation and reduction of [2Fe-2S] clusters. We previously proposed that superoxide (O2•-) has a direct role as a signal for E. coli SoxR and that the sensitivity of the E. coli SoxR response to O2•- is 10-fold higher than that of...
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