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Article

Gene expression profiling of glucocorticoid-inhibited osteoblasts

1 Aug 2004

Abstract excerpt

Glucocorticoid (GC) treatment for the management of autoimmune and inflammatory diseases is associated with decreased bone formation and increased risk for fracture. In MC3T3-E1 cell cultures, 0.1-1 microM dexamethasone (DEX) arrests development of the osteoblast phenotype when administration commences at a commitment stage around the time of confluency. To gain new insights into GC-induced osteoporosis, we...

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PMID: 15291752
DOI: 10.1677/jme.0.0330175

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