Article

Modulation of ossification and inflammatory pathways during dexamethasone-induced <i>in vitro</i> osteogenesis

2026-02-13

Abstract excerpt

<h4>Background</h4> Dexamethasone (DEX) is used in vitro to promote osteogenic differentiation of human bone marrow mesenchymal stromal cells (hBMSCs). In clinical use, however, glucocorticoids induce osteoblast and osteocyte apoptosis while increasing osteoclast survival, leading overall to osteoporosis and high fracture risk. The overall impact of DEX on the differentiation of human progenitor cells remains co...

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Literature Corpus work: 7a254949-99cc-5caf-abd8-0fa51cba5f39
DOI: 10.64898/2026.02.12.705508

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