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Article

Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells

4 Jan 2019

Abstract excerpt

Bone remodeling involves the coordinated actions of osteoclasts, which resorb the calcified bony matrix, and osteoblasts, which refill erosion pits created by osteoclasts to restore skeletal integrity and adapt to changes in mechanical load. Osteoblasts are derived from pluripotent mesenchymal stem cell precursors, which undergo differentiation under the influence of a host of local and environmental cues. To...

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PMID: 30608923
DOI: 10.1371/journal.pone.0204197

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