Article
Exploring alternative transcript structure in the human genome using blocks and InterPro.
Journal of bioinformatics and computational biology - 1 Jul 2003
Loraine Ann E, Helt Gregg A, Cline Melissa S, Siani-Rose Michael A
Abstract excerpt
Understanding how alternative splicing affects gene function is an important challenge facing modern-day molecular biology. Using homology-based, protein sequence analysis methods, it should be possible to investigate how transcript diversity impacts protein function. To test this, high-quality exon-intron structures were deduced for over 8000 human genes, including over 1300 (17 percent) that produce multiple...
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