Article

Predicting the Structural Impact of Human Alternative Splicing

2023-12-23

Abstract excerpt

<h4>Summary</h4> Protein structure prediction with neural networks is a powerful new method for linking protein sequence, structure, and function, but structures have generally been predicted for only a single isoform of each gene, neglecting splice variants. To investigate the structural implications of alternative splicing, we used AlphaFold2 to predict the structures of more than 11,000 human isoforms. We empl...

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Literature Corpus work: 33f32b21-d734-5719-bbbc-33215f19841f
DOI: 10.1101/2023.12.21.572928

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