Article

Do 5’ regions of human protein-coding genes contain the blueprints for alternative splicing?

2025-11-03

Abstract excerpt

To investigate alternative splicing capacity, we statistically compared the properties of human protein-coding genes with multiple transcript isoforms (MISOG) and single transcript isoforms (SISOG). Apart from global exon content, differential features are concentrated in the 5’ gene regions, with MISOG presenting complex 5’ untranslated region architecture and a distinctive flanking environment around first 5’ in...

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Literature Corpus work: 35e5132d-d2ea-5a34-97b9-0d17f28b0ea7
DOI: 10.1101/2025.11.01.686005

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