Article

Building alternative splicing and evolution-aware sequence-structure maps for protein repeats

2023-04-30

Abstract excerpt

Alternative splicing of repeats in proteins provides a mechanism for rewiring and fine-tuning protein interaction networks. In this work, we developed a robust and versatile method, ASPRING, to identify alternatively spliced protein repeats from gene annotations. ASPRING leverages evolutionary meaningful alternative splicing-aware hierarchical graphs to provide maps between protein repeats sequences and 3D structu...

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Literature Corpus work: 670e506e-27ff-5d5c-8723-c2031349a80e
DOI: 10.1101/2023.04.29.538821

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