Article
Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage.
Proceedings of the National Academy of Sciences of the United States of America - 10 Aug 2004
Neff Mark W, Robertson Kathryn R, Wong Aaron K, Safra Noa, Broman Karl W, Slatkin Montgomery, Mealey Katrina L, Pedersen Niels C
Abstract excerpt
A mutation in the canine multidrug resistance gene, MDR1, has previously been associated with drug sensitivities in two breeds from the collie lineage. We exploited breed phylogeny and reports of drug sensitivity to survey other purebred populations that might be genetically at risk. We found that the same allele, mdr1-1Delta, segregated in seven additional breeds, including two sighthounds that were not expected...
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