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Article

The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system

2 Aug 2004

Abstract excerpt

We report a critical role for the T-box transcription factor Tbx5 in development and maturation of the cardiac conduction system. We find that Tbx5 is expressed throughout the central conduction system, including the atrioventricular bundle and bundle branch conduction system. Tbx5 haploinsufficiency in mice (Tbx5(del/+)), a model of human Holt-Oram syndrome, caused distinct morphological and functional defects...

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Identifiers

PMID: 15289437
DOI: 10.1242/dev.01265

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