Article
FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells.
Oncogene - 17 May 2001
Mattila M M, Ruohola J K, Valve E M, Tasanen M J, Seppänen J A, Härkönen P L
Abstract excerpt
Fibroblast growth factor 8 (FGF-8) is a secreted heparin-binding protein, which has transforming potential. Alternative splicing of the mouse Fgf-8 gene potentially codes for eight protein isoforms (a-h) which differ in their transforming capacity in transfected cells. S115 mouse mammary tumor cells express a transformed phenotype and secrete FGF-8 in an androgen-dependent manner. In order to study the role of...
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