Rapid tumor development and potent vascularization are independent events in carcinoma producing FGF-1 or FGF-2.

doi:10.1038/sj.onc.1205935

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Article

Rapid tumor development and potent vascularization are independent events in carcinoma producing FGF-1 or FGF-2.

Oncogene - 21 Nov 2002

Billottet Clotilde, Janji Bassam, Thiery Jean-Paul, Jouanneau Jacqueline

Abstract excerpt

FGF-1 and FGF-2 are pleiotropic growth factors for many cell types, operating through the activation of specific transmembrane FGF receptors (FGFRs). The role of these factors in tumor progression was investigated, with specific discrimination between their autocrine and non autocrine cellular activity. The rat bladder carcinoma NBT-II cells were engineered to produce FGF-1 or 18 kDa FGF-2 in the presence or...

Topics

Animals
Autocrine Communication
Carcinoma
Disease Progression
Endothelial Growth Factors
Epithelial Cells
Female
Fibroblast Growth Factor 1
Fibroblast Growth Factor 2
Gene Expression Regulation, Neoplastic

Intercellular Signaling Peptides and Proteins

Lymphokines

Matrix Metalloproteinases

Mesoderm

Mice

Mice, Nude

Neoplasm Invasiveness

Neoplasm Proteins

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