Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy.

Cancer science - 1 May 2006

Miyamoto Shingo, Yagi Hiroshi, Yotsumoto Fusanori, Kawarabayashi Tatsuhiko, Mekada Eisuke

Abstract excerpt

HB-EGF, a member of the EGF family of growth factors, exerts its biological activity through activation of the EGFR and other ErbB receptors. HB-EGF participates in diverse biological processes, including heart development and maintenance, skin wound healing, eyelid formation, blastocyst implantation, progression of atherosclerosis and tumor formation, through the activation of signaling molecules downstream of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Movement
Share to Epidermal Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heparin-binding EGF-like Growth Factor

Share to Intercellular Signaling Peptides and Proteins

Share to Models, Biological

Share to Neoplasms

Share to Ovarian Neoplasms

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 16630129
DOI: 10.1111/j.1349-7006.2006.00188.x
PMCID: PMC11159358

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy.PMID 16630129Read ↗

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a mediator of multiple physiological and pathological pathways.Semantic proximity Read ↗

HB-EGF is a potent inducer of tumor growth and angiogenesis.Semantic proximity Read ↗

Ectodomain shedding of HB-EGF: a potential target for cancer therapy.Semantic proximity Read ↗

Suppression of the biological activities of the epidermal growth factor (EGF)-like domain by the heparin-binding domain of heparin-binding EGF-like Growth Factor.Semantic proximity Read ↗

Discovery of HB-EGF binding peptides and their functional characterization in ovarian cancer cell linesSemantic proximity Read ↗

HB-EGF Is a Promising Therapeutic Target for Lung Cancer with Secondary Mutation of EGFRT790M.Semantic proximity Read ↗

Role of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Oxidative Stress-Associated Metabolic Diseases.Semantic proximity Read ↗

EGF mutant receptor vIII as a molecular target in cancer therapy.Semantic proximity Read ↗

Development of a human epidermal growth factor derivative with EGFR-blocking and depleted biological activities: A comparative in vitro study using EGFR-positive breast cancer cells.Semantic proximity Read ↗

Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF.Semantic proximity Read ↗

Transgenic and knock-out mice for deciphering the roles of EGFR ligands.Semantic proximity Read ↗

Significance of the association between heparin‐binding epidermal growth factor‐like growth factor and CD9 in human gastric cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.