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Article

Genetic modifiers regulating DNA replication and double-strand break repair are associated with differences in mammary tumors in mouse models of Li-Fraumeni syndrome.

Oncogene - 1 Aug 2021

Majhi Prabin Dhangada, Griner Nicholas B, Mayfield Jacob A, Compton Shannon, Kane Jeffrey J, Baptiste Trevor A, Dunphy Karen A, Roberts Amy L, Schneider Sallie S, Savage Evan M, Patel Divyen, Blackburn Anneke C, Maurus Kim Joana, Wiesmüller Lisa, Jerry D Joseph

Abstract excerpt

Breast cancer is the most common tumor among women with inherited variants in the TP53 tumor suppressor, but onset varies widely suggesting interactions with genetic or environmental factors. Rodent models haploinsufficent for Trp53 also develop a wide variety of malignancies associated with Li-Fraumeni syndrome, but BALB/c mice are uniquely susceptible to mammary tumors and is genetically linked to the Suprmam1...

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Share to Disease Susceptibility
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to DNA Replication

Share to Genes, Modifier

Share to Genetic Loci

Share to Li-Fraumeni Syndrome

Share to Recombinational DNA Repair

Source

Open in PubMed Open full text

Identifiers

PMID: 34183771
DOI: 10.1038/s41388-021-01892-5
PMCID: PMC8349885

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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