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Article

Effects of amiodarone on mutant Na+/Ca2+ exchangers expressed in CCL 39 cells.

European journal of pharmacology - 2 Aug 2004

Watanabe Yasuhide, Iwamoto Takahiro, Matsuoka Isao, Ono Tomoyuki, Shigekawa Munekazu, Kimura Junko

Abstract excerpt

Using the whole cell voltage clamp, we reported previously that amiodarone acutely inhibits Na+/Ca2+ exchange current (INCX) in guinea pig cardiac ventricular myocytes. Intracellular application of trypsin via the patch pipette attenuated the blocking effect of amiodarone, suggesting that amiodarone affects the Na+/Ca2+ exchanger (NCX) from the cytoplasmic side. Here, we attempted to detect the site of amiodarone...

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Identifiers

PMID: 15288574
DOI: 10.1016/j.ejphar.2004.06.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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