A combination study of benzyloxyphenyl NCX inhibitor and its insensitive Slc8a1 mutation knock-in mouse reveals NCX1-specific physiological functions.

Abstract excerpt

The Na+/Ca2+ exchanger (NCX) is a bidirectional transporter that is controlled by membrane potential and transmembrane gradients of Na+ and Ca2+. Benzyloxyphenyl NCX inhibitors such as SEA0400 and KB-R7943 are widely used for NCX research. However, since these inhibitors have shown to possess somewhat nonspecific actions, it is necessary to discriminate between the specific and nonspecific actions in their...

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• Aniline Compounds
• Gene Knock-In Techniques
• Mice
• Mice, Inbred C57BL
• Mutation