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Article

Na+ channels in cardiac and neuronal cells derived from a mouse embryonal carcinoma cell line.

The Journal of physiology - 1 Dec 1993

Arreola J, Spires S, Begenisich T

Abstract excerpt

1. Cells from a pluripotent murine embryonal carcinoma cell line (P19) were differentiated in vitro into cells with neurone- and cardiac-like phenotypes. Cells treated with 0.5 microM retinoic acid developed into neurone-like cells possessing extensive neurites. Dimethyl sulphoxide treatment (0.5%) produced large, spontaneously contracting cell aggregates with many properties of cardiac cells. 2. The neurone- and...

Topics

Animals
Carcinoma, Embryonal
Cell Differentiation
Dimethyl Sulfoxide
Electrophysiology
Kinetics
Membrane Potentials
Mice
Myocardium
Neurons
Phenotype
Sodium Channel Blockers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sodium Channels

Tetrodotoxin

Tretinoin

Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 8145145
DOI: 10.1113/jphysiol.1993.sp019947
PMCID: PMC1160487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8145145-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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