Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

What drives recombination hotspots to repeat DNA in humans?

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 27 Apr 2010

McVean Gil

Abstract excerpt

Recombination between homologous, but non-allelic, stretches of DNA such as gene families, segmental duplications and repeat elements is an important source of mutation. In humans, recent studies have identified short DNA motifs that both determine the location of 40 per cent of meiotic cross-over hotspots and are significantly enriched at the breakpoints of recurrent non-allelic homologous recombination (NAHR)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crossing Over, Genetic
Share to DNA
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Genetic Variation

Share to Recombination, Genetic

Share to Repetitive Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 20308096
DOI: 10.1098/rstb.2009.0299
PMCID: PMC2871820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

What drives recombination hotspots to repeat DNA in humans?PMID 20308096Read ↗

A chromosomal rearrangement hotspot can be identified from population genetic variation and is coincident with a hotspot for allelic recombination.Semantic proximity Read ↗

The rise and fall of a human recombination hot spot.Semantic proximity Read ↗

Origins of chromosomal rearrangement hotspots in the human genome: evidence from the AZFa deletion hotspots.Semantic proximity Read ↗

Human polymorphism around recombination hotspots.Semantic proximity Read ↗

Analysis of deletion breakpoints from 1,092 humans reveals details of mutation mechanisms.Semantic proximity Read ↗

A fine-scale map of recombination rates and hotspots across the human genome.Semantic proximity Read ↗

Why recombination hotspots?Semantic proximity Read ↗

A common sequence motif associated with recombination hot spots and genome instability in humans.Semantic proximity Read ↗

Frequency of nonallelic homologous recombination is correlated with length of homology: evidence that ectopic synapsis precedes ectopic crossing-over.Semantic proximity Read ↗

Mammalian meiotic recombination hot spots.Semantic proximity Read ↗

GT repeats are associated with recombination on human chromosome 22.Semantic proximity Read ↗

Co-evolution between PRDM9 and target sites and the Recombination Hotspot ParadoxSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.