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Article

Folate metabolic pathways in <i>Leishmania</i>

24 Oct 2011

Abstract excerpt

Trypanosomatid parasitic protozoans of the genus Leishmania are autotrophic for both folate and unconjugated pteridines. Leishmania salvage these metabolites from their mammalian hosts and insect vectors through multiple transporters. Within the parasite, folates are reduced by a bifunctional DHFR (dihydrofolate reductase)-TS (thymidylate synthase) and by a novel PTR1 (pteridine reductase 1), which reduces both...

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PMID: 22023442
DOI: 10.1042/bse0510063

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