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Article

Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence.

The Journal of biological chemistry - 15 Dec 2006

Vickers Tim J, Orsomando Giuseppe, de la Garza Rocío Díaz, Scott David A, Kang Song O, Hanson Andrew D, Beverley Stephen M

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) is the sole enzyme responsible for generation of 5-methyltetrahydrofolate, which is required for methionine synthesis and provision of methyl groups via S-adenosylmethionine. Genome analysis showed that Leishmania species, unlike Trypanosoma brucei and Trypanosoma cruzi, contain genes encoding MTHFR and two distinct methionine synthases. Leishmania MTHFR...

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Source

Identifiers

PMID: 17032644
DOI: 10.1074/jbc.M608387200

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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