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Article

Resistance to sulphadrug-based antifolate therapy in malaria: are we looking in the right place?

Tropical medicine & international health : TM & IH - 1 Jun 2006

Platteeuw J J

Abstract excerpt

Sulphadrug treatment failure in malaria therapy cannot solely be ascribed to the build-up of genetic resistance within the parasitic genome. Although numerous in vitro studies have tried to determine the exact genetic markers that could predict treatment outcome in patients, this research has not been conclusive. Sulphadrugs work by competitive inhibition with pABA at one point of the pathway to de novo folate...

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Identifiers

PMID: 16772001
DOI: 10.1111/j.1365-3156.2006.01646.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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