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Article

Dissecting the protein-protein interface between beta-lactamase inhibitory protein and class A beta-lactamases.

The Journal of biological chemistry - 8 Oct 2004

Zhang Zhen, Palzkill Timothy

Abstract excerpt

beta-Lactamase inhibitory protein (BLIP) binds and inhibits a diverse collection of class A beta-lactamases at a wide range of affinities. Alanine-scanning mutagenesis was previously performed to identify the amino acid sequence requirements of BLIP for inhibiting TEM-1 beta-lactamase and SME-1 beta-lactamase. Two hotspots of binding energy, one from each domain of BLIP, were identified (Zhang, Z., and Palzkill,...

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Source

Identifiers

PMID: 15284234
DOI: 10.1074/jbc.M406157200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Dissecting the protein-protein interface between beta-lactamase inhibitory protein and class A beta-lactamases.PMID 15284234Read ↗

Determinants of binding affinity and specificity for the interaction of TEM-1 and SME-1 beta-lactamase with beta-lactamase inhibitory protein.Semantic proximity Read ↗

Role of β-lactamase residues in a common interface for binding the structurally unrelated inhibitory proteins BLIP and BLIP-II.Semantic proximity Read ↗

Binding hot spots in the TEM1-BLIP interface in light of its modular architecture.Semantic proximity Read ↗

A β-lactamase inhibitory protein mutant displays high potency and a broad inhibition profile due to an altered binding mode with β-lactamases.Semantic proximity Read ↗

Categorization of hotspots into three types - weak, moderate and strong to distinguish protein-protein versus protein-peptide interactions.Semantic proximity Read ↗

The modular architecture of protein-protein binding interfaces.Semantic proximity Read ↗

Exploring the coupling of dynamic residues in TEM-1 β-lactamase and their role in activity.Semantic proximity Read ↗

Structural and functional characterization of an active site-influencing variant (IMP-1-F218Y) in IMP-1 metallo-β-lactamase.Semantic proximity Read ↗

Computational alanine scanning of protein-protein interfaces.Semantic proximity Read ↗

Low-stringency selection of TEM1 for BLIP shows interface plasticity and selection for faster binders.Semantic proximity Read ↗

Protein-protein binding affinities by pulse proteolysis: application to TEM-1/BLIP protein complexes.Semantic proximity Read ↗

Promiscuous Protein Binding as a Function of Protein Stability.Semantic proximity Read ↗

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