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Article

Role of β-lactamase residues in a common interface for binding the structurally unrelated inhibitory proteins BLIP and BLIP-II.

Protein science : a publication of the Protein Society - 1 Sept 2014

Fryszczyn Bartlomiej G, Adamski Carolyn J, Brown Nicholas G, Rice Kacie, Huang Wanzhi, Palzkill Timothy

Abstract excerpt

The β-lactamase inhibitory proteins (BLIPs) are a model system for examining molecular recognition in protein-protein interactions. BLIP and BLIP-II are structurally unrelated proteins that bind and inhibit TEM-1 β-lactamase. Both BLIPs share a common binding interface on TEM-1 and make contacts with many of the same TEM-1 surface residues. BLIP-II, however, binds TEM-1 over 150-fold tighter than BLIP despite the...

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Identifiers

PMID: 24947275
DOI: 10.1002/pro.2505
PMCID: PMC4243995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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