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Article

PKCα activation of p120-catenin serine 879 phospho-switch disassembles VE-cadherin junctions and disrupts vascular integrity.

Circulation research - 31 Aug 2012

Vandenbroucke St Amant Emily, Tauseef Mohammad, Vogel Stephen M, Gao Xiao-Pei, Mehta Dolly, Komarova Yulia A, Malik Asrar B

Abstract excerpt

RATIONALE: Adherens junctions (AJs) are the primary intercellular junctions in microvessels responsible for endothelial barrier function. Homophilic adhesion of vascular endothelial (VE) cadherin forms AJs, which are stabilized by binding of p120-catenin (p120). p120 dissociation from VE-cadherin results in loss of VE-cadherin homotypic interaction and AJ disassembly; however, the signaling mechanisms regulating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22798526
DOI: 10.1161/CIRCRESAHA.112.269654
PMCID: PMC3518422

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