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Article

Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stress.

The Journal of biological chemistry - 2 Sept 2011

Tanjore Harikrishna, Cheng Dong-Sheng, Degryse Amber L, Zoz Donald F, Abdolrasulnia Rasul, Lawson William E, Blackwell Timothy S

Abstract excerpt

Expression of mutant surfactant protein C (SFTPC) results in endoplasmic reticulum (ER) stress in type II alveolar epithelial cells (AECs). AECs have been implicated as a source of lung fibroblasts via epithelial-to-mesenchymal transition (EMT); therefore, we investigated whether ER stress contributes to EMT as a possible mechanism for fibrotic remodeling. ER stress was induced by tunicamyin administration or...

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Source

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Identifiers

PMID: 21757695
DOI: 10.1074/jbc.M110.181164
PMCID: PMC3162456

Genes

SFTPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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