Estrogens and Progesterone Promote Persistent <i>CCND1</i> Gene Activation during G ₁ by Inducing Transcriptional Derepression via c- <i>Jun</i> /c- <i>Fos</i> /Estrogen Receptor (Progesterone Receptor) Complex Assembly to a Distal Regulatory Element and Recruitment of Cyclin D1 to Its Own Gene Promoter

Abstract excerpt

Transcriptional activation of the cyclin D1 gene (CCND1) plays a pivotal role in G(1)-phase progression, which is thereby controlled by multiple regulatory factors, including nuclear receptors (NRs). Appropriate CCND1 gene activity is essential for normal development and physiology of the mammary gland, where it is regulated by ovarian steroids through a mechanism(s) that is not fully elucidated. We report here...

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