Basic Helix-Loop-Helix Proteins Bind to <i>TrkB</i> and <i>p21^Cip1</i> Promoters Linking Differentiation and Cell Cycle Arrest in Neuroblastoma Cells

Abstract excerpt

Differentiation of precursor into specialized cells involves an increasing restriction in proliferative capacity, culminating in cell cycle exit. In this report we used a human neuroblastoma cell line to study the molecular mechanisms that coordinate cell cycle arrest and neuronal differentiation. Exposure to retinoic acid (RA), a differentiation agent in many cell types, causes an upregulation of neurotrophin...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neuroblastoma Research and Treatments
• Share to Ubiquitin and proteasome pathways
• Share to Virus-based gene therapy research