Article
Phenotype-associated env gene variation among eight related human immunodeficiency virus type 1 clones: evidence for in vivo recombination and determinants of cytotropism outside the V3 domain.
Journal of virology - 1 Oct 1992
Groenink M, Andeweg A C, Fouchier R A, Broersen S, van der Jagt R C, Schuitemaker H, de Goede R E, Bosch M L, Huisman H G, Tersmette M
Abstract excerpt
The nucleotide sequences of the env genes of eight phenotypically heterogeneous human immunodeficiency virus type 1 (HIV-1) clones recovered from a single individual within a 3-week period were compared. In addition, the accessory gene sequences for four of these clones were obtained. Variation among most accessory genes was limited. In contrast, pronounced phenotype-associated sequence variation was observed in...
Topics
- Amino Acid Sequence
- Gene Products, env
- Genes, Viral
- Genes, env
- Genetic Variation
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Molecular Sequence Data
- Peptide Fragments