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Article

Intercompartmental recombination of HIV-1 contributes to env intrahost diversity and modulates viral tropism and sensitivity to entry inhibitors.

Journal of virology - 1 Jun 2011

Brown Richard J P, Peters Paul J, Caron Catherine, Gonzalez-Perez Maria Paz, Stones Leanne, Ankghuambom Chiambah, Pondei Kemebradikumo, McClure C Patrick, Alemnji George, Taylor Stephen, Sharp Paul M, Clapham Paul R, Ball Jonathan K

Abstract excerpt

HIV-1 circulates within an infected host as a genetically heterogeneous viral population. Viral intrahost diversity is shaped by substitutional evolution and recombination. Although many studies have speculated that recombination could have a significant impact on viral phenotype, this has never been definitively demonstrated. We report here phylogenetic and subsequent phenotypic analyses of envelope genes...

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Identifiers

PMID: 21471230
DOI: 10.1128/JVI.00131-11
PMCID: PMC3126287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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