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Article

Maintenance of glycoprotein-determined phenotype in an HIV type 1 (pNL43) env gene-cassetting system.

AIDS research and human retroviruses - 1 Nov 2001

Zheng N N, Daniels R S

Abstract excerpt

Here we report the construction and use of a full-length env gene-cassetting system, C2, based on the HIV-1 infectious molecular clone NL43. C2 produces virus with the same phenotype as NL43 but with 2-fold lower growth kinetics. The latter probably relates to alteration in the vpu and/or nef genes. C2-env chimeras of macrophage-tropic and T cell-tropic laboratory strains and primary HIV-1 isolates retain the...

Topics

Amino Acid Sequence
Base Sequence
Cell Line
Cloning, Molecular
Gene Products, env
Genes, env
HIV Infections
HIV-1
Humans
Molecular Sequence Data
Phenotype
Recombinant Fusion Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, DNA

Source

Identifiers

PMID: 11709094
DOI: 10.1089/08892220152644205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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